13Oct 2017

The term real-world evidence (RWE) is commonly used to refer to non-randomized clinical trial (RCT) data generated in a healthcare setting, which sometimes extends to cover patient socio-economic data and environmental data. Irrespective of the definition, RWE is seen to offer significant advantages over randomized controlled trials (RCTs), which despite being recognized as the gold […]

21Sep 2017

Missing data are a big concern in any research project; however, despite investigators’ best efforts they are often unavoidable. Missing outcomes have two effects: they reduce precision and power, and they may introduce bias. The statistician can’t do much about the loss of precision, except to make best use of the data that are available; […]

24Nov 2016

While scientists, clinicians, and regulators play critical roles in understanding and communicating the benefits and risks of drugs/medical treatments, only patients live with their medical conditions and make choices regarding their personal care. They provide a unique voice and unique perspective. In recent years, more and more studies are focusing on patient reported outcomes (PROs). […]

30Sep 2016

Health systems have developed at different speeds, and with differing degrees of complexity throughout the twentieth century, reflecting the diverse political and social conditions in each country. Notwithstanding their diversity, all systems, however, share a common reason for their existence, namely the improvement of health for their entire populations. To attain this goal a health […]