Health Economics & Outcomes Research
HEOR Services
Providing Innovative Solutions and Services Across All HEOR Domains
Evidence Planning
We meticulously identify gaps in current evidence in the context of client requirement to prepare a comprehensive roadmap to plan our evidence synthesis activities.
Identify evidence gaps
PICOS and SLR eligibility criteria generation
SLR protocol preparation and registration
Search strategy planning
Literature Reviews
MarksMan specializes in high-quality evidence synthesis through end-to-end support for systematic literature reviews. We are experts in all stages of the SLRs, right from reconstructing SLR objectives to PICOS headings, till preparing SLR report. We hunt for evidence from all possible sources, and generate credible evidence.
PICOS, search strategy preparing and executing
SLR protocol preparation and registration
Database and grey literature search, screening, data extraction, quality assessment
SLR report writing, periodic updates
Meta-Analysis
Our statisticians are proficient in data analysis using appropriate forms of statistical methods and generate insights about various outcomes. We have expertise in multiple forms of direct and indirect comparisons, using both frequentist and Bayesian methods.
Direct and indirect treatment comparisons
Meta-analyses, network meta-analysis
Bayesian and frequentist statistics
R, Stata, SPSS, WinBUGS/OpenBUGS, RevMan, and other software
Economic Modeling
MarksMan assists in development of health economic models to support reimbursements, health technology assessment (HTA) submissions, and to optimize market access strategies.
Decision tree model, Markov model, partitioned survival model
Different types of cost analysis: CEA, CUA, COI/ BOI, CBA, BMI
De-novo model conceptualization
Country-specific modeling adaptations
Clinical Evaluation Reports
Medical devices seeking marketing authorization must submit a detailed clinical evaluation report (CER) to the regulators. Our team is experienced with preparing CERs for medical devices in accordance with the relevant guidelines, including MEDDEV 2.7/1
Clinical evaluation planning (CEP) and clinical evaluation report (CER)
Background, current knowledge, state-of-the-art (SOTA)
Detailed literature analysis for device under evaluation (DUE)
Medical device details: design, materials, mode of operation, site of use, etc
QOL/PRO Analysis
Capturing patient-centered outcomes to assess the true impact of healthcare interventions on quality of life.
Evidence synthesis on humanistic outcomes including quality of life (QoL) and other Patient-reported outcomes (PROs)
Integration of QOL/PRO data into health economic models.
Development and validation of PRO instruments tailored to patient needs.