Comparative Effectiveness Research

10Jan 2023

Meta-analyses summarize data from head-to-head trials to evaluate pairs of treatments that have been directly compared.[1] However, in certain circumstances, multiple therapies are of interest, and no data is available on their direct comparison. In such cases, indirect treatment comparison (ITC) is performed for synthesizing evidence surrounding treatments of interest.[2] ITC assumes that the studies […]

25Jul 2022

Randomized controlled trials (RCTs) are the mainstay of clinical research; it is estimated that about 18,000 RCTs are published each year. However, traditional RCTs usually take a long time to complete, are expensive, and the results are challenging to generalize to the real-world since they are derived under ideal conditions with strict inclusion and exclusion […]