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08May
Risk of Bias Assessment During Systematic Literature Reviews: Why and How?
A systematic literature review (SLR) is considered the highest form of evidence due to its rigorous approach through which every relevant piece of published or unpublished literature that is currently […]
13Apr
Using ‘Limits’ While Developing SLR Search Strategy: Advantages and Disadvantages
Systematic literature reviews (SLR) are a crucial tool to identify high-quality evidence for research, policy, and practice. The success of SLRs heavily relies on the performance of the literature search […]
10Apr
The Importance of CHARMS Checklist in the SLRs of Clinical Prediction Models
Clinical prediction models (CPMs) are statistical models that use patient characteristics and clinical variables to estimate the probability of a particular health outcome, such as a disease or adverse event. […]
31Mar
The Role and Importance of SLRs and RWE in Drug Price Negotiations in the USA
The cost of prescription drugs is a significant burden on patients and the healthcare system, especially in countries such as the USA. High drug prices can strain government programs, such […]
10Jan
An Overview of Methods for Indirect Treatment Comparisons in Healthcare Decision-making
Meta-analyses summarize data from head-to-head trials to evaluate pairs of treatments that have been directly compared.[1] However, in certain circumstances, multiple therapies are of interest, and no data is available […]
28Dec
Certainty of Evidence in Systematic Reviews: The GRADE Approach
When seeking answers to clinical questions about efficacy or other aspects of a proposed intervention, health professionals often look for reliable evidence. Systematic literature reviews (SLRs) serve this purpose, by […]
24Nov
Different Types of Systematic Literature Review: a Beginner’s Guide
Literature reviews play a vital role in fulfilling the primary goal of any evidence-based research by aiding in decision-making with transparent and impacting results.[1] With advances in all medical fields […]
03Nov
How to Report a Systematic Review? The PRISMA Statement and its Extensions
Healthcare decisions for patients and public health policies should be supported by the best available research evidence. To ensure the hierarchy of the evidence, an evidence pyramid was conceptualized, with […]
06Dec
Importance of Searching Clinical Trial Registries for Systematic Reviews
Results from over half of all conducted randomized controlled trials (RCTs), especially those with negative or unfavorable results, never get published. This means, searching only electronic databases that index published […]