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15May
The HARmonized Protocol Template to Enhance Reproducibility (HARPER) in RWE
Real World Evidence (RWE) is generated as a result of the real-world usage of drugs, and thus can complement the RCT (randomized controlled trial) evidence that is generated in controlled […]
08May
Risk of Bias Assessment During Systematic Literature Reviews: Why and How?
A systematic literature review (SLR) is considered the highest form of evidence due to its rigorous approach through which every relevant piece of published or unpublished literature that is currently […]
13Apr
Using ‘Limits’ While Developing SLR Search Strategy: Advantages and Disadvantages
Systematic literature reviews (SLR) are a crucial tool to identify high-quality evidence for research, policy, and practice. The success of SLRs heavily relies on the performance of the literature search […]
10Apr
The Importance of CHARMS Checklist in the SLRs of Clinical Prediction Models
Clinical prediction models (CPMs) are statistical models that use patient characteristics and clinical variables to estimate the probability of a particular health outcome, such as a disease or adverse event. […]
31Mar
The Role and Importance of SLRs and RWE in Drug Price Negotiations in the USA
The cost of prescription drugs is a significant burden on patients and the healthcare system, especially in countries such as the USA. High drug prices can strain government programs, such […]
06Mar
Living HTAs: Helping to Keep Health Technology Evidence in Real-Time
Health technology assessment (HTA) is a process that evaluates the safety, efficacy, and cost-effectiveness of medical technologies, such as drugs, medical devices, and diagnostic tests, in order to inform decision-making […]
13Feb
Living SLRs: an Approach to Enhance Accuracy and Recency of SLRs
Living systematic literature reviews (SLRs) are a type of SLRs that are continually updated by periodically including relevant new evidence as and when it becomes available. SLRs are often considered […]
10Jan
An Overview of Methods for Indirect Treatment Comparisons in Healthcare Decision-making
Meta-analyses summarize data from head-to-head trials to evaluate pairs of treatments that have been directly compared.[1] However, in certain circumstances, multiple therapies are of interest, and no data is available […]
02Jan
The STaRT RWE Template: Improving Reporting of RWE Studies
Improvements in healthcare digitalization and accelerated regulatory approvals of novel interventions have boosted the possibilities for gathering real-world data (RWD) and using the resultant real-world evidence (RWE) to support the […]