Systematic reviews (SRs) are the embodiment of the evidence-based approaches, and they have reformed clinical decision-making in almost all therapy areas. The approach of SRs was essentially developed to fulfil the need of the medical practitioners to obtain precise and consistent information about the efficacy and safety of a clinical intervention, diagnostic procedure, or a […]
Systematic reviews (SRs) often face a major challenge while identifying all the relevant research, including randomised controlled trials (RCTs) irrespective of their publication status.(1) Unpublished, selectively reported, or non-reported research can lead to poorer quality clinical trials, thus leading to suboptimal care delivery. It also overlooks the opportunities for potential scientific progress.(2) Such incomplete publication […]
The world today is observing an exponential growth in the volume and variety of the real-world data (RWD). Thanks to the technological advancements and the rise in the use of integrated electronic medical records (EMRs), RWD is ever more accessible and applicable in the regulatory domain as well as outcomes research. The evidence from randomized […]
Clinical practice should ideally rely on robust scientific evidence, the standard for which are systematic reviews and meta-analyses of all randomised controlled trials (RCTs). (1,2) Therapeutic decisions in healthcare must be informed by clinical research findings, and patients and prescribers must be able to trust the presented research evidence. However, this evidence can be considered […]
Systematic reviews (SRs) are crucial in health and scientific research as they offer a thorough understanding of the findings from research. (1) They provide critical information on different aspects of research, such as answers to the questions not often addressed by individual studies, problems in primary research that need to be avoided in future studies, […]
In a data-driven world, where everything can be digitalized, drug regulators and sponsors are increasingly looking beyond the confines of clinical trials. The use of real-world data (RWD) is becoming common in the clinical development process of a drug. RWD enhances the drug approval process, helps sponsors understand how a particular intervention really performs, and […]
Systematic reviews (SRs) are incredibly crucial for healthcare decision-making, as they often provide a reliable summary of evidence on the comparison among healthcare interventions. They identify, assess, and combine the results of similar but individual studies and help to clarify the known and unknown benefits and risks associated with drugs, devices, and other healthcare interventions. […]
The need for transparency in drug pricing is getting severe with increased spending on medications with each passing year. Drug spending in the US, without the discounts, has been reported to be $309.5 billion in the year 2015, which is about 8.5% higher than that reported in the preceding year. (1) As a result, undoubtedly, […]
Drug prices are generally not static. The price of a drug is high when it is newly introduced in the market and is on-patent. After the expiry of patent, the introduction of generic drugs in the market can significantly reduce the price of the drug, sometimes even up to 90% less. In India, drug prices […]
