#MarksManInsights

Neovascular Age-Related Macular Degeneration (nAMD) is a progressive ocular disease characterized by the abnormal growth of new blood vessels in the choroid, leading to retinal damage and central vision loss. This pathological neovascularization results in leakage, hemorrhage and fibrosis which ultimately disrupts the macula along with the central portion of the retina responsible for detailed vision. Agents targeting VEGF (vascular endothelial growth factor) administered intravitreally have revolutionized the treatment of nAMD. Our client wanted to understand the efficacy and safety of different anti-VEGF medications used in the management of nAMD. To address this, we conducted a comprehensive data extraction and risk of bias assessment of over 70 studies. This project stood out by the large number of linked publications that some of the included studies had. We extracted data pertaining to efficacy, safety, and tolerability, and also performed risk of bias assessment for all the included articles.
Therapy area: Therapy Area: Ophthalmology