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04Sep
Challenges of Single-Arm Trials in Network Meta-Analyses (NMAs)
Network Meta-Analysis (NMA) is a sophisticated statistical technique that allows researchers to simultaneously compare multiple treatments using a combination of direct and indirect evidence. While NMAs have revolutionized evidence synthesis, […]
28Aug
Elevating Evidence Synthesis: Unveiling the Research Integrity Assessment (RIA) Tool
The bedrock of evidence-based decision-making rests on the integrity of systematic reviews, which rely on the credibility of the studies they encompass. While bias assessment and risk of bias evaluation […]
22Aug
Unveiling the Economic Significance of Genomic and Genetic Testing in Healthcare
In the landscape of modern healthcare, revolutionary advancements are continually reshaping our understanding of genetics and genomics. One such breakthrough that has gained significant attention is genomic and genetic testing. […]
08Aug
Matching-Adjusted Indirect Comparisons (MAICs): What, Why, and How?
Meta-analysis is crucial in evidence-based medicine as it combines data from multiple studies for more precise treatment effect estimates. However, when head-to-head clinical trials directly comparing treatments are scarce, Indirect […]
03Aug
Hybrid Study Designs: Combining Existing and New Data for Valuable Insights
Hybrid study designs are research methodologies that seamlessly blend elements from multiple study designs to address specific research questions comprehensively. Such a hybrid approach allows researchers to capitalize on the […]
17Jul
Using AI to Accurately Assess Risk of Bias in Published Articles: Are We There Yet?
In the realm of medical research, the credibility and accuracy of published articles are paramount. Healthcare professionals rely on these articles to make informed decisions regarding patient care, treatment modalities, […]
12Jul
Evaluating Medical Devices: How Do RCT Data and RWD Fit Together?
Medical devices play a critical role in modern healthcare, aiding in diagnosing, treating, and managing various diseases and conditions. Before these devices are approved for widespread use, they undergo rigorous […]
06Jul
Challenges in the Use of Real-World Evidence for Pharmacoeconomic Modeling
Pharmacoeconomic modeling is vital for healthcare decision-making, enabling stakeholders to evaluate the value and cost-effectiveness of pharmaceutical interventions. These models offer insights into clinical and economic outcomes, aiding policymakers, providers, […]
16Jun
External Control Arms (ECA): Optimizing Submissions to HTA Agencies
In the realm of pharmaceutical development, the pursuit of safe and effective treatments is paramount. To achieve this, rigorous clinical trials are conducted to evaluate the efficacy and safety of […]