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02Jan
The STaRT RWE Template: Improving Reporting of RWE Studies
Improvements in healthcare digitalization and accelerated regulatory approvals of novel interventions have boosted the possibilities for gathering real-world data (RWD) and using the resultant real-world evidence (RWE) to support the […]
28Dec
Certainty of Evidence in Systematic Reviews: The GRADE Approach
When seeking answers to clinical questions about efficacy or other aspects of a proposed intervention, health professionals often look for reliable evidence. Systematic literature reviews (SLRs) serve this purpose, by […]
24Nov
Different Types of Systematic Literature Review: a Beginner’s Guide
Literature reviews play a vital role in fulfilling the primary goal of any evidence-based research by aiding in decision-making with transparent and impacting results.[1] With advances in all medical fields […]
03Nov
How to Report a Systematic Review? The PRISMA Statement and its Extensions
Healthcare decisions for patients and public health policies should be supported by the best available research evidence. To ensure the hierarchy of the evidence, an evidence pyramid was conceptualized, with […]
25Aug
The Economics of Social Determinants of Health and Health Equity
The World Health Organization Health (WHO) defines health as “a state of complete physical, mental and social well-being; and not merely the absence of disease or infirmity.”[1] Health is influenced […]
11Aug
Generating Clinical Evidence From Electronic Health Records and Patient Registries
Both electronic health records (EHRs) and patient registries store and use patient-related clinical information. However, they are conceptualized for different purposes. Both are a significant source of real-world evidence (RWE) […]
25Jul
Comparative Effectiveness in Real-World Settings through Pragmatic Clinical Trials
Randomized controlled trials (RCTs) are the mainstay of clinical research; it is estimated that about 18,000 RCTs are published each year. However, traditional RCTs usually take a long time to […]
21Jul
RWE Framework by NICE (UK) for Optimizing RWD Collection and RWE Generation
Evidence from randomized clinical trials (RCTs) continues to be the standard reference point for treatment efficacy across the world. However, RCTs enrol patients based on strict inclusion and exclusion criteria, […]
27Jun
The Expanding Role of Real-World Evidence in Evaluation of Medical Devices
Concerns about the consistency of the post-marketing surveillance (PMS) for safety of medical devices is well known across the world. Only around 13% of post-marketing surveillance (PMS) clinical studies are […]