Improvements in healthcare digitalization and accelerated regulatory approvals of novel interventions have boosted the possibilities for gathering real-world data (RWD) and using the resultant real-world evidence (RWE) to support the […]
When seeking answers to clinical questions about efficacy or other aspects of a proposed intervention, health professionals often look for reliable evidence. Systematic literature reviews (SLRs) serve this purpose, by […]
Literature reviews play a vital role in fulfilling the primary goal of any evidence-based research by aiding in decision-making with transparent and impacting results.[1] With advances in all medical fields […]
Healthcare decisions for patients and public health policies should be supported by the best available research evidence. To ensure the hierarchy of the evidence, an evidence pyramid was conceptualized, with […]
The World Health Organization Health (WHO) defines health as “a state of complete physical, mental and social well-being; and not merely the absence of disease or infirmity.”[1] Health is influenced […]
Both electronic health records (EHRs) and patient registries store and use patient-related clinical information. However, they are conceptualized for different purposes. Both are a significant source of real-world evidence (RWE) […]
Randomized controlled trials (RCTs) are the mainstay of clinical research; it is estimated that about 18,000 RCTs are published each year. However, traditional RCTs usually take a long time to […]
Evidence from randomized clinical trials (RCTs) continues to be the standard reference point for treatment efficacy across the world. However, RCTs enrol patients based on strict inclusion and exclusion criteria, […]
Concerns about the consistency of the post-marketing surveillance (PMS) for safety of medical devices is well known across the world. Only around 13% of post-marketing surveillance (PMS) clinical studies are […]